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    rbx1 ring-box 1, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 449846, updated on 9-Dec-2024

    Summary

    Official Symbol
    rbx1provided by ZNC
    Official Full Name
    ring-box 1, E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041008-106
    See related
    Ensembl:ENSDARG00000038030 AllianceGenome:ZFIN:ZDB-GENE-041008-106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7137515; zgc:136444
    Summary
    Predicted to enable cullin family protein binding activity and ubiquitin protein ligase activity. Acts upstream of or within ventricular trabecula myocardium morphogenesis. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in female organism. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See rbx1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25101960..25107802, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (24971412..24977254, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene X-prolyl aminopeptidase 3, mitochondrial Neighboring gene ST13 Hsp70 interacting protein Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene chondroadherin-like a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cullin family protein binding  
    enables metal ion binding  
    enables ubiquitin protein ligase activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    part_of cullin-RING ubiquitin ligase complex  
    is_active_in nucleus  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RBX1
    NP_001077013.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083544.1 → NP_001077013.1  E3 ubiquitin-protein ligase RBX1

      See identical proteins and their annotated locations for NP_001077013.1

      Status: VALIDATED

      Source sequence(s)
      BX470254
      UniProtKB/TrEMBL
      A0A8M1NDS7, A4FUL3
      Related
      ENSDARP00000055431.6, ENSDART00000055432.8
      Conserved Domains (1) summary
      cd16485
      Location:40 → 101
      mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      25101960..25107802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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