U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tcn2 transcobalamin II [ Danio rerio (zebrafish) ]

    Gene ID: 407646, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    tcn2provided by ZNC
    Official Full Name
    transcobalamin IIprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4648
    See related
    Ensembl:ENSDARG00000036481 AllianceGenome:ZFIN:ZDB-GENE-030131-4648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tcn2l; wu:fd46e10; si:ch211-102c2.6
    Summary
    Enables cobalamin binding activity. Acts upstream of or within cobalamin transport. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in intestine; liver; and yolk syncytial layer. Used to study vitamin B12 deficiency. Human ortholog(s) of this gene implicated in Parkinson's disease; megaloblastic anemia; and transcobalamin II deficiency. Orthologous to human TCN2 (transcobalamin 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tcn2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26795502..26806101)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (26195349..26205948)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-102c2.8 Neighboring gene coiled-coil domain containing 117 Neighboring gene RAB, member RAS oncogene family-like 6b Neighboring gene si:ch211-102c2.4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The cobalamin-binding protein in zebrafish is an intermediate between the three cobalamin-binding proteins in human. Greibe E, et al. PLoS One, 2012. PMID 22532867, Free PMC Article
    2. Loss of the Vitamin B-12 Transport Protein Tcn2 Results in Maternally Inherited Growth and Developmental Defects in Zebrafish. Benoit CR, et al. J Nutr, 2021 Sep 4. PMID 34132337, Free PMC Article
    3. Functional and phylogenetic characterization of noncanonical vitamin B(12)-binding proteins in zebrafish suggests involvement in cobalamin transport. Benoit CR, et al. J Biol Chem, 2018 Nov 9. PMID 30237171, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the Vitamin B-12 Transport Protein Tcn2 Results in Maternally Inherited Growth and Developmental Defects in Zebrafish.
      Title: Loss of the Vitamin B-12 Transport Protein Tcn2 Results in Maternally Inherited Growth and Developmental Defects in Zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cobalamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cobalamin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cobalamin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cobalamin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cobalamin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cobalamin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cobalt ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transcobalamin-2
    Names
    transcobalamin II, like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123231.2 → NP_001116703.1  transcobalamin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      CU041374, EH509290, EH535398
      UniProtKB/TrEMBL
      A0A8M1NIB7, F2Z4S3
      Related
      ENSDARP00000053000.4, ENSDART00000053001.6
      Conserved Domains (2) summary
      pfam01122
      Location:17 → 318
      Cobalamin_bind; Eukaryotic cobalamin-binding protein
      pfam14478
      Location:347 → 421
      DUF4430; Domain of unknown function (DUF4430)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      26795502..26806101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools