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    ppp1r10 protein phosphatase 1, regulatory subunit 10 [ Danio rerio (zebrafish) ]

    Gene ID: 192329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp1r10provided by ZNC
    Official Full Name
    protein phosphatase 1, regulatory subunit 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-15
    See related
    Ensembl:ENSDARG00000032651 AllianceGenome:ZFIN:ZDB-GENE-020419-15
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe15d12; fk54b08; ppp1r10l; CHUNP6885; wu:fe15d12; wu:fk54b08
    Summary
    Predicted to enable protein phosphatase 1 binding activity. Predicted to be located in chromatin. Predicted to be part of PTW/PP1 phosphatase complex. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppp1r10 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (30409881..30422239, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (30822568..30834926, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 13b Neighboring gene anterior gradient 2 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene ATP-binding cassette, sub-family F (GCN20), member 1 Neighboring gene si:ch211-215a10.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A genome-wide survey of Major Histocompatibility Complex (MHC) genes and their paralogues in zebrafish. Sambrook JG, et al. BMC Genomics, 2005 Nov 4. PMID 16271140, Free PMC Article
    2. Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain. Wang S, et al. Front Genet, 2017. PMID 29354154, Free PMC Article
    3. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 1 regulatory subunit 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277109.1 → NP_001264038.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

      See identical proteins and their annotated locations for NP_001264038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BG737363, BI533789, BX510301, BX547939, CT677904, EB872952, EB917670, GO936108
      UniProtKB/TrEMBL
      A0A8M9PG75, A3KPX4, F1RA09
      Related
      ENSDARP00000043553.3, ENSDART00000043554.4
      Conserved Domains (3) summary
      pfam00642
      Location:758 → 781
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cl26464
      Location:237 → 371
      Atrophin-1; Atrophin-1 family

    2. NM_212568.2 → NP_997733.2  serine/threonine-protein phosphatase 1 regulatory subunit 10

      See identical proteins and their annotated locations for NP_997733.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BX510301, BX547939
      UniProtKB/TrEMBL
      A0A8M9PG75, A3KPX4, F1RA09
      Related
      ENSDARP00000120235.1, ENSDART00000144121.2
      Conserved Domains (3) summary
      pfam00642
      Location:758 → 781
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl00146
      Location:102 → 146
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cl26464
      Location:237 → 371
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      30409881..30422239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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