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    kat7b K(lysine) acetyltransferase 7b [ Danio rerio (zebrafish) ]

    Gene ID: 323181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kat7bprovided by ZNC
    Official Full Name
    K(lysine) acetyltransferase 7bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1901
    See related
    Ensembl:ENSDARG00000031770 AllianceGenome:ZFIN:ZDB-GENE-030131-1901
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    kat7; myst2; fi16d05; wu:fb92a01; wu:fi16d05
    Summary
    Predicted to enable chromatin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Acts upstream of or within blood vessel development. Predicted to be located in chromatin. Predicted to be part of histone H3-K14 acetyltransferase complex. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kat7b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (5981333..5998900, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5947749..5965280, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene distal-less homeobox 3b Neighboring gene distal-less homeobox 4b Neighboring gene si:ch211-131k2.2 Neighboring gene prostaglandin E synthase 3 like Neighboring gene glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation. Yan MS, et al. J Biol Chem, 2018 Mar 23. PMID 29414790, Free PMC Article
    2. Cytoplasmic polyadenylation-mediated translational control of maternal mRNAs directs maternal-to-zygotic transition. Winata CL, et al. Development, 2018 Jan 8. PMID 29229769
    3. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
    4. Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish. Zhou WH, et al. J Biol Chem, 2023 Oct. PMID 37660921, Free PMC Article
    5. Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Aanes H, et al. Genome Res, 2011 Aug. PMID 21555364, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone H3-K14 acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase KAT7
    Names
    K(lysine) acetyltransferase 7
    MYST histone acetyltransferase 2
    MYST-HAT2
    NP_997800.1
    XP_021335701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212635.1 → NP_997800.1  histone acetyltransferase KAT7

      See identical proteins and their annotated locations for NP_997800.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045314
      UniProtKB/TrEMBL
      Q6DI19, Q7ZW29
      Related
      ENSDARP00000021648.8, ENSDART00000004896.10
      Conserved Domains (3) summary
      pfam01530
      Location:144 → 170
      zf-C2HC; Zinc finger, C2HC type
      pfam01853
      Location:351 → 529
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:287 → 545
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      5981333..5998900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480026.2 → XP_021335701.1  histone acetyltransferase KAT7 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QIK1
      Conserved Domains (2) summary
      pfam01530
      Location:127 → 155
      zf-C2HC; Zinc finger, C2HC type
      cl27485
      Location:190 → 549
      MOZ_SAS; MOZ/SAS family
    Nucleotide Protein Strain
    Heading Accession and Version

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