atoh1a atonal bHLH transcription factor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atoh1aprovided by ZNC
Official Full Name: atonal bHLH transcription factor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-17
See related: Ensembl:ENSDARG00000055294 AllianceGenome:ZFIN:ZDB-GENE-990415-17
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ath1; atoh1; zath1; ZATH-1; Zath1a; Atoh1.1; zgc:136417
Summary: Enables chromatin binding activity. Acts upstream of or within mechanoreceptor differentiation. Predicted to be active in nucleus. Is expressed in hindbrain neural keel; nervous system; neural tube; otic epithelium; and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human ATOH1 (atonal bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (29593978..29595615)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (29584746..29586383)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

interplay of atoh1 genes in the lower rhombic lip during hindbrain morphogenesis
Title: The interplay of atoh1 genes in the lower rhombic lip during hindbrain morphogenesis.
A genetic network of sensory determinant, Atoh1 (and Sox9a), play critical roles in otic neural development.
Title: Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish.
Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear.
Title: Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear.
Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish.
Title: Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish.
atoh1a and atoh1b are together necessary for hair cell development. These genes crossregulate each other but are differentially required during distinct developmental periods
Title: Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch.
in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1
Title: Proneural gene requirement for hair cell differentiation in the zebrafish lateral line.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear receptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within posterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein atonal homolog 1a

Names: atonal homolog 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131091.2 → NP_571166.2 protein atonal homolog 1a

Status: VALIDATED

Source sequence(s)

AL807792, EH591361, EH608855

UniProtKB/TrEMBL

A0A8M1P6Y3, B0R059

Related

ENSDARP00000105581.2, ENSDART00000077642.6

Conserved Domains (1) summary

cd19713
Location:114 → 177

bHLH_TS_ATOH1; basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar proteins