tsr1 TSR1 ribosome maturation factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tsr1provided by ZNC
Official Full Name: TSR1 ribosome maturation factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3762
See related: Ensembl:ENSDARG00000007744 AllianceGenome:ZFIN:ZDB-GENE-030131-3762
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc52b09; wu:fc52b09; zgc:123319
Summary: Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in nucleolus. Orthologous to human TSR1 (TSR1 ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (25635325..25656331)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (25700037..25721067)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc52b09 (e-PCR), detects polymorphism
- UniSTS:189307

fc49d03.y1 (e-PCR)
- UniSTS:194010

fc78e07.y1 (e-PCR)
- UniSTS:194523

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables U3 snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pre-rRNA-processing protein TSR1 homolog

Names: TSR1, 20S rRNA accumulation, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037370.2 → NP_001032447.2 pre-rRNA-processing protein TSR1 homolog

Status: VALIDATED

Source sequence(s)

CT027805

UniProtKB/TrEMBL

A0A0R4IKX4, A0A8M1N870

Related

ENSDARP00000136648.1, ENSDART00000162240.2

Conserved Domains (4) summary

COG5177
Location:20 → 793

COG5177; Uncharacterized conserved protein [Function unknown]

pfam04950
Location:509 → 791

RIBIOP_C; 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal

pfam08142
Location:239 → 321

AARP2CN; AARP2CN (NUC121) domain

cl21455
Location:141 → 268

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

25635325..25656331

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157568.5 → XP_005157625.1 pre-rRNA-processing protein TSR1 homolog isoform X1

UniProtKB/TrEMBL

A0A8M2B3Q8, E7FCX4

Related

ENSDARP00000052644.6, ENSDART00000052645.8

Conserved Domains (4) summary

COG5177
Location:20 → 807

COG5177; Uncharacterized conserved protein [Function unknown]

pfam04950
Location:523 → 805

RIBIOP_C; 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal

pfam08142
Location:239 → 321

AARP2CN; AARP2CN (NUC121) domain

cl21455
Location:141 → 268

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases