st3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: st3gal5provided by ZNC
Official Full Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-060322-1
See related: Ensembl:ENSDARG00000037556 AllianceGenome:ZFIN:ZDB-GENE-060322-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: st3Gal-V; wu:fc08a12
Summary: Enables lactosylceramide alpha-2,3-sialyltransferase activity. Acts upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including digestive system; heart; nervous system; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in salt and pepper syndrome. Orthologous to human ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (9481451..9499220)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (9175420..9193194)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc08a12.x1 (e-PCR)
- UniSTS:192319

fc08a12.x1 (e-PCR)
- UniSTS:192320

fb95c09.y1 (e-PCR)
- UniSTS:191875

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lactosylceramide alpha-2,3-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactosylceramide alpha-2,3-sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables lactosylceramide alpha-2,3-sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lactosylceramide alpha-2,3-sialyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glycosphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lactosylceramide alpha-2,3-sialyltransferase

Names: GM3 synthase; ganglioside GM3 synthase; st3gal5-r1; zST3GalV-1

NP_955810.2

EC 2.4.3.9

XP_005157196.1

EC 2.4.3.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199516.2 → NP_955810.2 lactosylceramide alpha-2,3-sialyltransferase

See identical proteins and their annotated locations for NP_955810.2

Status: PROVISIONAL

Source sequence(s)

BC125822

UniProtKB/TrEMBL

A0JMC3

Related

ENSDARP00000054689.5, ENSDART00000054690.7

Conserved Domains (1) summary

pfam00777
Location:88 → 356

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

9481451..9499220

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157139.5 → XP_005157196.1 lactosylceramide alpha-2,3-sialyltransferase isoform X1

UniProtKB/TrEMBL

A0A8M2B3B0, F1RCA6

Conserved Domains (1) summary

pfam00777
Location:88 → 356

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)