clint1a clathrin interactor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: clint1aprovided by ZNC
Official Full Name: clathrin interactor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2590
See related: Ensembl:ENSDARG00000025535 AllianceGenome:ZFIN:ZDB-GENE-030131-2590
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: enth; epn4; clint1; wu:fa05f05; wu:fb97f11; wu:fc12e09; zgc:103447
Summary: Predicted to enable clathrin binding activity and phospholipid binding activity. Acts upstream of or within regulation of epidermis development. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Is expressed in epidermis and ventral fin fold. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (35370034..35387533)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (35029720..35047219)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We further show that decreasing endocytosis in romeharsha mutant and clint1 morphants rescues or mitigates the effect on cell size, cell proliferation and morphological phenotype.
Title: Functional characterisation of romeharsha and clint1 reaffirms the link between plasma membrane homeostasis, cell size maintenance and tissue homeostasis in developing zebrafish epidermis.
PLLP recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis.
Title: Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs.
A zebrafish line with a mutation in the cargo adaptor protein Clint1 exhibits psoriasis-like phenotypes including epithelial hyperproliferation and leukocyte infiltration.
Title: The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.

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General gene information

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Markers

fc12e09.x1 (e-PCR)
- UniSTS:203793

AI626276 (e-PCR)
- UniSTS:206142

fb97f11.x1 (e-PCR)
- UniSTS:191945

fa05f05.s1 (e-PCR)
- UniSTS:202219

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: clathrin interactor 1a

Names: clathrin interactor 1; enthoprotin; epsin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003412.1 → NP_001003412.1 clathrin interactor 1a

See identical proteins and their annotated locations for NP_001003412.1

Status: PROVISIONAL

Source sequence(s)

AY648742

UniProtKB/TrEMBL

Q6DRL7

Related

ENSDARP00000114046.1, ENSDART00000144702.3

Conserved Domains (1) summary

cd03571
Location:23 → 146

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...