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    tctn2 tectonic family member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 563835, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tctn2provided by ZNC
    Official Full Name
    tectonic family member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-751
    See related
    Ensembl:ENSDARG00000035633 AllianceGenome:ZFIN:ZDB-GENE-030131-751
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb44f11; wu:fb44f11; si:ch211-89f7.3
    Summary
    Acts upstream of or within determination of left/right symmetry. Predicted to be part of MKS complex. Human ortholog(s) of this gene implicated in Joubert syndrome 24 and Meckel syndrome 8. Orthologous to human TCTN2 (tectonic family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tctn2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (13394640..13426890)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (12894407..12926543)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2L 3b Neighboring gene chemokine (C-C motif) ligand 19a, tandem duplicate 1 Neighboring gene chemokine (C-C motif) ligand 19a, tandem duplicate 2 Neighboring gene SEC14-like lipid binding 8 Neighboring gene novel protein similar to human and mouse cyclin M4 (CNNM4) Neighboring gene uncharacterized LOC101885304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects. Liu C, et al. Genome Med, 2018 May 30. PMID 29843777, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MKS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tectonic-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      13394640..13426890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_687198.9 → XP_692290.5  tectonic-2

      UniProtKB/TrEMBL
      A0A8N7UV03, F1R5E2
      Related
      ENSDARP00000051668.7, ENSDART00000051669.8
      Conserved Domains (1) summary
      pfam07773
      Location:176 → 440
      DUF1619; Protein of unknown function (DUF1619)
    Nucleotide Protein Strain
    Heading Accession and Version

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