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    ndufb8 NADH:ubiquinone oxidoreductase subunit B8 [ Danio rerio (zebrafish) ]

    Gene ID: 393829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndufb8provided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1858
    See related
    Ensembl:ENSDARG00000010113 AllianceGenome:ZFIN:ZDB-GENE-040426-1858
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nduf8; zgc:77718
    Summary
    Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Is expressed in muscle and skeletal muscle. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 32. Orthologous to human NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndufb8 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (48469755..48477013, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (48486433..48493691, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene stearoyl-CoA desaturase (delta-9-desaturase) Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene uncharacterized LOC137496859 Neighboring gene Rho GTPase activating protein 44b Neighboring gene uncharacterized LOC108191761 Neighboring gene testis expressed 47

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ccn6 Is Required for Mitochondrial Integrity and Skeletal Muscle Function in Zebrafish. Sengupta A, et al. Front Cell Dev Biol, 2021. PMID 33644064, Free PMC Article
    2. Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish. Shi L, et al. Int J Mol Sci, 2023 May 18. PMID 37240290, Free PMC Article
    3. CCN6 influences transcription and controls mitochondrial mass and muscle organization. Ganguly A, et al. FASEB J, 2023 Mar. PMID 36794678
    4. BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Zhuang J, et al. Chemosphere, 2020 Nov. PMID 32947675
    5. Opa1 is required for proper mitochondrial metabolism in early development. Rahn JJ, et al. PLoS One, 2013. PMID 23516612, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77718

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8
    NP_957149.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200855.1 → NP_957149.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

      See identical proteins and their annotated locations for NP_957149.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062842
      UniProtKB/TrEMBL
      A0A8M1PBV6, Q6P5L5
      Related
      ENSDARP00000095947.3, ENSDART00000105176.4
      Conserved Domains (1) summary
      pfam05821
      Location:22 → 188
      NDUF_B8; NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      48469755..48477013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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