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    atp5f1c ATP synthase F1 subunit gamma [ Danio rerio (zebrafish) ]

    Gene ID: 336957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atp5f1cprovided by ZNC
    Official Full Name
    ATP synthase F1 subunit gammaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8901
    See related
    Ensembl:ENSDARG00000045514 AllianceGenome:ZFIN:ZDB-GENE-030131-8901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    atp5c1; zgc:73209; wu:fk34c05
    Summary
    Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to act upstream of or within ATP biosynthetic process and proton transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of proton-transporting ATP synthase complex, catalytic core F(1). Orthologous to human ATP5F1C (ATP synthase F1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See atp5f1c in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (25173218..25181582, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (25184020..25192384, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene GATA binding protein 3 Neighboring gene TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene uncharacterized LOC137491552 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Xiao B, et al. Zebrafish, 2017 Jun. PMID 28318412
    2. Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Chen D, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30916346, Free PMC Article
    3. Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. Lee JY, et al. Sci Total Environ, 2021 Jun 1. PMID 33548715
    4. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
    5. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Ayobahan SU, et al. Sci Rep, 2019 Apr 29. PMID 31036921, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit gamma, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
    NP_001315479.1
    NP_001315480.1
    NP_956335.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328550.1 → NP_001315479.1  ATP synthase subunit gamma, mitochondrial isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      BX640594, EH461834, EH484827, EH528823
      UniProtKB/TrEMBL
      A0A8M1P9B7, Q5RH26
      Conserved Domains (1) summary
      TIGR01146
      Location:21 → 292
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    2. NM_001328551.1 → NP_001315480.1  ATP synthase subunit gamma, mitochondrial isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BX640594, EH447408, EH461834, EH484827, EH528823
      UniProtKB/TrEMBL
      A0A8M1P526
      Conserved Domains (1) summary
      TIGR01146
      Location:21 → 292
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    3. NM_200041.2 → NP_956335.2  ATP synthase subunit gamma, mitochondrial isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      BX640594
      UniProtKB/TrEMBL
      A0A8M1P9B7, Q5RH26
      Related
      ENSDARP00000066929.6, ENSDART00000066930.7
      Conserved Domains (1) summary
      TIGR01146
      Location:21 → 292
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      25173218..25181582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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