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    msh6 mutS homolog 6 (E. coli) [ Danio rerio (zebrafish) ]

    Gene ID: 260437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    msh6provided by ZNC
    Official Full Name
    mutS homolog 6 (E. coli)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020905-3
    See related
    Ensembl:ENSDARG00000104541 AllianceGenome:ZFIN:ZDB-GENE-020905-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb326; wu:fb36c12
    Summary
    Enables guanine/thymine mispair binding activity. Acts upstream of or within maintenance of DNA repeat elements. Predicted to be part of MutSalpha complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; immature eye; neural tube; optic primordium; and ventral mesoderm. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See msh6 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (48358471..48381066)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (48067441..48090018)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 12 Neighboring gene uncharacterized LOC137487326 Neighboring gene F-box protein 11a Neighboring gene forkhead box N2a Neighboring gene uncharacterized LOC100149084

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of zebrafish (Danio rerio) MutS homolog 6(MSH6) and noncoordinate expression of MSH6 gene activity and G-T mismatch binding proteins in zebrafish larvae. Yeh FL, et al. J Exp Zool A Comp Exp Biol, 2003 Jun 1. PMID 12945748
    2. Cloning of the mismatch recognition protein MSH2 from zebrafish (Danio rerio) and its developmental stage-dependent mRNA expression. Yeh FL, et al. Biochim Biophys Acta, 2004 Oct 21. PMID 15488992
    3. Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos. Feitsma H, et al. Nucleic Acids Res, 2008 Jul. PMID 18522974, Free PMC Article
    4. Sublethal levels of cadmium down-regulate the gene expression of DNA mismatch recognition protein MutS homolog 6 (MSH6) in zebrafish (Danio rerio) embryos. Hsu T, et al. Chemosphere, 2010 Oct. PMID 20696460
    5. Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors. Feitsma H, et al. Cancer Res, 2008 Jul 1. PMID 18593904

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and characterization of novel knockout mutants of the three major MMR genes, mlh1, msh2, and msh6, in zebrafish that develop tumors at low frequencies.
      Title: Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors.
    2. Studied MSH6 gene expression in developing zebrafish and the influence of MSH6 expression on the production of mismatch binding factors.
      Title: Molecular cloning of zebrafish (Danio rerio) MutS homolog 6(MSH6) and noncoordinate expression of MSH6 gene activity and G-T mismatch binding proteins in zebrafish larvae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanine/thymine mispair binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables mismatched DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mismatched DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within maintenance of DNA repeat elements IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MutSalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA mismatch repair protein Msh6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182860.1 → NP_878280.1  DNA mismatch repair protein Msh6

      See identical proteins and their annotated locations for NP_878280.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044350
      UniProtKB/TrEMBL
      Q803S7
      Related
      ENSDARP00000131172.1, ENSDART00000171080.2
      Conserved Domains (7) summary
      COG0249
      Location:406 → 1335
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam01624
      Location:406 → 524
      MutS_I; MutS domain I
      pfam05188
      Location:537 → 693
      MutS_II; MutS domain II
      pfam05190
      Location:933 → 1025
      MutS_IV; MutS family domain IV
      pfam05192
      Location:740 → 828
      MutS_III; MutS domain III
      cl02554
      Location:83 → 188
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
      cl21455
      Location:1095 → 1322
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      48358471..48381066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224897.1 → XP_068080998.1  DNA mismatch repair protein Msh6 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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