lipia lipase, member Ia [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lipiaprovided by ZNC
Official Full Name: lipase, member Iaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-242
See related: Ensembl:ENSDARG00000007108 AllianceGenome:ZFIN:ZDB-GENE-040801-242
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: liph; fb08f08; zgc:91985; wu:fb08f08
Summary: Predicted to enable phospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in notochord. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to several human genes including LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (34945033..34972755, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (34910543..34938265, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipase member H

NP_001003499.1

EC 3.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003499.1 → NP_001003499.1 lipase member H precursor

See identical proteins and their annotated locations for NP_001003499.1

Status: PROVISIONAL

Source sequence(s)

BC078354

UniProtKB/Swiss-Prot

Q6DBU8

UniProtKB/TrEMBL

A0A8M9PQD8

Related

ENSDARP00000014304.6, ENSDART00000023838.8

Conserved Domains (1) summary

cd00707
Location:43 → 327

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...