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    map4k5 mitogen-activated protein kinase kinase kinase kinase 5 [ Danio rerio (zebrafish) ]

    Gene ID: 334565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    map4k5provided by ZNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6497
    See related
    Ensembl:ENSDARG00000039125 AllianceGenome:ZFIN:ZDB-GENE-030131-6497
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fl74c10; zgc:55719; zgc:55985; wu:fl74c10
    Summary
    Predicted to enable MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See map4k5 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36705591..36761454, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36579761..36648348, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene distal membrane arm assembly component 2 like Neighboring gene cyclin dependent kinase like 1 (CDC2 related kinase) Neighboring gene atlastin GTPase 1 Neighboring gene salvador family WW domain containing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Fassier C, et al. Nat Neurosci, 2010 Nov. PMID 20935645
    2. Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90. Pfeiffer J, et al. Dev Biol, 2018 Apr 15. PMID 29477339
    3. Disruption of Trim9 function abrogates macrophage motility in vivo. Tokarz DA, et al. J Leukoc Biol, 2017 Dec. PMID 29021367, Free PMC Article
    4. A high level of liver-specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in transgenic zebrafish. Nguyen AT, et al. Dis Model Mech, 2011 Nov. PMID 21729876, Free PMC Article
    5. Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Liu Y, et al. Front Genet, 2020. PMID 32849832, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55719

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 5
    NP_956207.1
    XP_005157034.1
    XP_005157038.1
    XP_009305737.1
    XP_021336201.1
    XP_021336202.1
    XP_021336204.1
    XP_021336205.1
    XP_021336206.1
    XP_068081030.1
    XP_068081031.1
    XP_068081032.1
    XP_068081033.1
    XP_068081034.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199913.2 → NP_956207.1  mitogen-activated protein kinase kinase kinase kinase 5

      See identical proteins and their annotated locations for NP_956207.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055001
      UniProtKB/TrEMBL
      Q7ZUA2
      Related
      ENSDARP00000034684.6, ENSDART00000029824.8
      Conserved Domains (3) summary
      smart00036
      Location:544 → 858
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:20 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      36705591..36761454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224933.1 → XP_068081034.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X10

    2. XM_068224929.1 → XP_068081030.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B3T3

    3. XM_021480527.2 → XP_021336202.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9K2
      Conserved Domains (2) summary
      smart00036
      Location:559 → 874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    4. XM_068224932.1 → XP_068081033.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X10

    5. XM_068224931.1 → XP_068081032.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X9

    6. XM_005156981.5 → XP_005157038.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X8

      UniProtKB/TrEMBL
      A0A8M2B328
      Conserved Domains (3) summary
      smart00036
      Location:531 → 846
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:20 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    7. XM_009307462.4 → XP_009305737.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X7

      UniProtKB/TrEMBL
      A0A8M3AZ98, B8A6G9
      Conserved Domains (3) summary
      smart00036
      Location:544 → 858
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:20 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    8. XM_068224930.1 → XP_068081031.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X6

    9. XM_005156977.5 → XP_005157034.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B3T3
      Conserved Domains (3) summary
      smart00036
      Location:546 → 861
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:20 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    10. XM_021480531.2 → XP_021336206.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X4

      UniProtKB/TrEMBL
      A0A8M9QJK1
      Conserved Domains (2) summary
      smart00036
      Location:557 → 871
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    11. XM_021480530.2 → XP_021336205.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QNA9
      Conserved Domains (2) summary
      smart00036
      Location:557 → 872
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    12. XM_021480529.2 → XP_021336204.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QF91
      Conserved Domains (2) summary
      smart00036
      Location:559 → 873
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    13. XM_021480526.2 → XP_021336201.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9K2
      Conserved Domains (2) summary
      smart00036
      Location:559 → 874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
    Nucleotide Protein Strain
    Heading Accession and Version

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