erg ETS transcription factor ERG [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ergprovided by ZNC
Official Full Name: ETS transcription factor ERGprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-40
See related: Ensembl:ENSDARG00000077304 AllianceGenome:ZFIN:ZDB-GENE-041212-40
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:103429
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis and hemangioblast cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in hereditary lymphedema and myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (160340..167860, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (160340..167860, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A combination of gain-of-function and loss-of-function studies suggested a redundant yet specific role for erg in both angioblast specification/proliferation and early angiogenesis, and a synergistic interaction with the critical ETS factor etsrp.
Title: The role of the ETS factor erg in zebrafish vasculogenesis.
fli1, and etsrp, demonstrated that erg and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin
Title: Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis.

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General gene information

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Markers

fa11a02.s1 (e-PCR)
- UniSTS:202290

G41722 (e-PCR)
- UniSTS:32824

AA494792 (e-PCR)
- UniSTS:186818

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemangioblast cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcriptional regulator ERG

Names: erg1; v-ets avian erythroblastosis virus E26 oncogene homolog; v-ets erythroblastosis virus E26 oncogene like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008616.1 → NP_001008616.1 transcriptional regulator ERG

See identical proteins and their annotated locations for NP_001008616.1

Status: PROVISIONAL

Source sequence(s)

BC086811

UniProtKB/TrEMBL

Q5PR65

Related

ENSDARP00000102806.3, ENSDART00000108780.4

Conserved Domains (2) summary

cd08540
Location:77 → 151

SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor

smart00413
Location:257 → 340

ETS; erythroblast transformation specific domain