polr1c RNA polymerase I and III subunit C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: polr1cprovided by ZNC
Official Full Name: RNA polymerase I and III subunit Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1495
See related: Ensembl:ENSDARG00000039400 AllianceGenome:ZFIN:ZDB-GENE-040426-1495
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:65973
Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Acts upstream of or within cartilage development; embryonic viscerocranium morphogenesis; and ribosome biogenesis. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Is expressed in several structures, including head; immature eye; midbrain; midbrain hindbrain boundary; and segmental plate. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (28690392..28694924)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (28559943..28564474)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data confirmed that polr1c is highly expressed in the facial region, and dysfunction of this gene by knockdown or knock-out resulted in mis-expression of neural crest cells during early development that leads to Treacher Collins Syndrome phenotype.
Title: Pathogenesis of POLR1C-dependent Type 3 Treacher Collins Syndrome revealed by a zebrafish model.
Our work therefore has uncovered tissue-specific roles for polr1c and polr1d in rRNA transcription, ribosome biogenesis, and neural crest and craniofacial development during embryogenesis.
Title: The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome.

Submit: New GeneRIF Correction

General gene information

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Markers

fc25d05.x1 (e-PCR)
- UniSTS:193253

fe11e10.y1 (e-PCR)
- UniSTS:196071

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase I activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase III activity	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerases I and III subunit RPAC1

Names: polymerase (RNA) I polypeptide C, 30kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200566.1 → NP_956860.1 DNA-directed RNA polymerases I and III subunit RPAC1

See identical proteins and their annotated locations for NP_956860.1

Status: PROVISIONAL

Source sequence(s)

BC056581

UniProtKB/TrEMBL

Q6PHE7

Related

ENSDARP00000112094.2, ENSDART00000128246.4

Conserved Domains (2) summary

cd07032
Location:50 → 340

RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III

smart00662
Location:62 → 337

RPOLD; RNA polymerases D