wif1 wnt inhibitory factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wif1provided by ZNC
Official Full Name: wnt inhibitory factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990712-17
See related: Ensembl:ENSDARG00000005541 AllianceGenome:ZFIN:ZDB-GENE-990712-17
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110507
Summary: Predicted to enable activin receptor binding activity and nodal binding activity. Acts upstream of or within habenula development; negative regulation of canonical Wnt signaling pathway; and swim bladder development. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including anterior swim bladder bud; nervous system; paraxial mesoderm; pharyngeal arch; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human WIF1 (WNT inhibitory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (12931738..12956718)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (12932930..12957869)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry.
Title: Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry.
Data describe the importance of proper level of Wnt signaling for normal development of swimbladder in Wif1 morphant zebrafish.
Title: Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within habenula development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swim bladder development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: wnt inhibitory factor 1

Names: WIF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131229.2 → NP_571304.2 wnt inhibitory factor 1 precursor

Status: VALIDATED

Source sequence(s)

BX119963

UniProtKB/Swiss-Prot

Q9W6F9

Related

ENSDARP00000019818.4, ENSDART00000016382.5