csnk1db casein kinase 1, delta b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: csnk1dbprovided by ZNC
Official Full Name: casein kinase 1, delta bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2385
See related: Ensembl:ENSDARG00000006125 AllianceGenome:ZFIN:ZDB-GENE-040426-2385
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: csnk1d; zgc:77627; wu:fb69b03; wu:fj97a05
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including organelle assembly; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway and protein phosphorylation. Predicted to be active in cytoplasm; nucleus; and spindle microtubule. Is expressed in several structures, including axis; brain; notochord; presumptive neural retina; and yolk syncytial layer. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome 2. Orthologous to human CSNK1D (casein kinase 1 delta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (33320537..33336787)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (33219554..33235804)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that CK1delta inhibition abolishes rhythmic pineal aanat2 mRNA expression.
Title: Casein kinase 1δ activity: a key element in the zebrafish circadian timing system.
The phosphorylation of p53 by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
Title: Isoform specific phosphorylation of p53 by protein kinase CK1.

Submit: New GeneRIF Correction

General gene information

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Markers

fb69b03.x1 (e-PCR)
- UniSTS:190976

fb69b03.x1 (e-PCR)
- UniSTS:190977

fc48c05.y1 (e-PCR)
- UniSTS:193978

fk21g04.y1 (e-PCR)
- UniSTS:200657

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: casein kinase I isoform delta-B

Names: CKI-delta-B; CKId-B

NP_998415.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213250.1 → NP_998415.1 casein kinase I isoform delta-B

See identical proteins and their annotated locations for NP_998415.1

Status: PROVISIONAL

Source sequence(s)

BC063953

UniProtKB/Swiss-Prot

Q4V962, Q6P3K7

Related

ENSDARP00000014900.8, ENSDART00000021491.9

Conserved Domains (2) summary

smart00219
Location:10 → 273

TyrKc; Tyrosine kinase, catalytic domain

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon