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    cdk12 cyclin dependent kinase 12 [ Danio rerio (zebrafish) ]

    Gene ID: 100149834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdk12provided by ZNC
    Official Full Name
    cyclin dependent kinase 12provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-294
    See related
    Ensembl:ENSDARG00000063726 AllianceGenome:ZFIN:ZDB-GENE-081104-294
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa01h10; si:ch73-79d13.1
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Predicted to be involved in positive regulation of transcription elongation by RNA polymerase II. Predicted to act upstream of or within RNA splicing; mRNA processing; and protein phosphorylation. Predicted to be located in nuclear speck. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdk12 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (4856338..4905342)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 1, like Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1B Neighboring gene StAR related lipid transfer domain containing 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007130.7 Chromosome 19 Reference GRCz11 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sequencing and De Novo Assembly of the Gonadal Transcriptome of the Endangered Chinese Sturgeon (Acipenser sinensis). Yue H, et al. PLoS One, 2015. PMID 26030930, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0904

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division protein kinase 12; cyclin-dependent kinase 12
    Names
    cdc2-related kinase, arginine/serine-rich-like
    cell division cycle 2-like 5 (cholinesterase-related cell division controller)
    cholinesterase-related cell division controller
    XP_003200579.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      4856338..4905342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003200531.6 → XP_003200579.2  cyclin-dependent kinase 12

      UniProtKB/TrEMBL
      A0A8M1RMR6, F1R6Y1
      Related
      ENSDARP00000087834.5, ENSDART00000093402.7
      Conserved Domains (2) summary
      smart00220
      Location:675 → 968
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:667 → 968
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    Nucleotide Protein Strain
    Heading Accession and Version

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