npl N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nplprovided by ZNC
Official Full Name: N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-926
See related: Ensembl:ENSDARG00000009390 AllianceGenome:ZFIN:ZDB-GENE-030131-926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:76930; wu:fb53b06
Summary: Predicted to enable N-acetylneuraminate lyase activity. Acts upstream of or within N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including fin bud; gut; muscle; vein; and yolk syncytial layer. Used to study myopathy. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (19489959..19500063)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (19458006..19467978)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb53b06.x1 (e-PCR)
- UniSTS:203301

AI496933 (e-PCR)
- UniSTS:206383

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acetylneuraminate lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylneuraminate lyase activity	IEA Inferred from Electronic Annotation more info
enables N-acetylneuraminate lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylneuraminate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylneuraminate catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within N-acetylneuraminate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in N-acetylneuraminate catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylneuraminate lyase

Names: N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; sialate lyase; sialate-pyruvate lyase; sialic acid aldolase; sialic acid lyase

NP_996934.2

EC 4.1.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207051.2 → NP_996934.2 N-acetylneuraminate lyase

See identical proteins and their annotated locations for NP_996934.2

Status: VALIDATED

Source sequence(s)

CR354400, EB855384, EB868386

UniProtKB/Swiss-Prot

Q6NYR8

UniProtKB/TrEMBL

A0A8N7V087, A9C3P6

Related

ENSDARP00000027094.8, ENSDART00000011258.9

Conserved Domains (1) summary

cl21457
Location:8 → 274

TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...