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    eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) [ Danio rerio (zebrafish) ]

    Gene ID: 327515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif3s10provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 3, subunit 10 (theta)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5726
    See related
    Ensembl:ENSDARG00000076815 AllianceGenome:ZFIN:ZDB-GENE-030131-5726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66194; zgc:77263; wu:fi15c03
    Summary
    Predicted to enable mRNA binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in formation of cytoplasmic translation initiation complex and translation reinitiation. Predicted to act upstream of or within translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3e; eukaryotic translation initiation factor 3 complex, eIF3m; and multi-eIF complex. Orthologous to human EIF3A (eukaryotic translation initiation factor 3 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eif3s10 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (19283986..19317570)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (19153021..19186588)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100330690 Neighboring gene uncharacterized LOC137487387 Neighboring gene empty spiracles homeobox 2 Neighboring gene RAB11 family interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Frøyset AK, et al. Sci Rep, 2016 Jul 12. PMID 27404450, Free PMC Article
    2. Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Doretto LB, et al. Cells, 2022 Apr 11. PMID 35455974, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation reinitiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3e IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of multi-eIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199820.2 → NP_956114.2  eukaryotic translation initiation factor 3 subunit A

      See identical proteins and their annotated locations for NP_956114.2

      Status: PROVISIONAL

      Source sequence(s)
      BC066670
      UniProtKB/Swiss-Prot
      Q6NYB1, Q6PCR7
      Related
      ENSDARP00000102398.3, ENSDART00000111462.5
      Conserved Domains (5) summary
      smart00753
      Location:426 → 498
      PAM; PCI/PINT associated module
      pfam09728
      Location:517 → 800
      Taxilin; Myosin-like coiled-coil protein
      cd16269
      Location:650 → 661
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:643 → 739
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:566 → 685
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      19283986..19317570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156611.3 → XP_005156668.1  eukaryotic translation initiation factor 3 subunit A isoform X1

      UniProtKB/Swiss-Prot
      Q6NYB1, Q6PCR7
      UniProtKB/TrEMBL
      A0A8M2B2X2
      Conserved Domains (5) summary
      smart00753
      Location:426 → 498
      PAM; PCI/PINT associated module
      pfam09728
      Location:517 → 800
      Taxilin; Myosin-like coiled-coil protein
      cd16269
      Location:650 → 661
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:643 → 739
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:566 → 685
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCR7.1 GenPept UniProtKB/Swiss-Prot:Q6PCR7

    Gene LinkOut

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