hsp90b1 heat shock protein 90, beta (grp94), member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsp90b1provided by ZNC
Official Full Name: heat shock protein 90, beta (grp94), member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-031002-1
See related: Ensembl:ENSDARG00000003570 AllianceGenome:ZFIN:ZDB-GENE-031002-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GP96; tra1; GRP94; tra-1; fb61d09; wu:fb61d09; wu:fq25g01
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Acts upstream of or within defense response to Gram-positive bacterium; otolith tethering; and response to hypoxia. Predicted to be located in melanosome and sarcoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum and perinuclear region of cytoplasm. Is expressed in several structures, including axis; hatching gland; integument; lateral line system; and polster. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (9836509..9843836)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (9835593..9842920)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd09f04.y1 (e-PCR)
- UniSTS:195076

fi50b11.y1 (e-PCR)
- UniSTS:197659

fi51f09.x1 (e-PCR)
- UniSTS:197677

fj91c09.y1 (e-PCR)
- UniSTS:200303

fb61d09.x1 (e-PCR)
- UniSTS:203382

fb61d09 (e-PCR)
- UniSTS:187301

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otolith tethering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endoplasmin

Names: heat shock protein 90kDa beta (grp94), member 1; tumor rejection antigen (gp96) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198210.2 → NP_937853.1 endoplasmin precursor

See identical proteins and their annotated locations for NP_937853.1

Status: PROVISIONAL

Source sequence(s)

BC063951

UniProtKB/TrEMBL

Q6P3K8, Q7T3L3

Related

ENSDARP00000013441.5, ENSDART00000004879.6

Conserved Domains (3) summary

PRK05218
Location:74 → 746

PRK05218; heat shock protein 90; Provisional

cd00075
Location:98 → 216

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

pfam00183
Location:257 → 755

HSP90; Hsp90 protein