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    cpb1 carboxypeptidase B1 (tissue) [ Danio rerio (zebrafish) ]

    Gene ID: 322412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpb1provided by ZNC
    Official Full Name
    carboxypeptidase B1 (tissue)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1132
    See related
    Ensembl:ENSDARG00000045442 AllianceGenome:ZFIN:ZDB-GENE-030131-1132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb60d07; wu:fb69b08
    Summary
    Predicted to enable metallocarboxypeptidase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in extracellular space. Is expressed in liver. Orthologous to human CPB1 (carboxypeptidase B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cpb1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (4755389..4765724, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (4723602..4733937, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 8a Neighboring gene uncharacterized LOC137489204 Neighboring gene angiotensin II receptor, type 1b Neighboring gene zic family member 1 (odd-paired homolog, Drosophila) Neighboring gene zic family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Akula S, et al. Dev Comp Immunol, 2022 Feb. PMID 34619175
    2. Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. Lyons PJ, et al. PLoS One, 2010 Sep 24. PMID 20885977, Free PMC Article
    3. Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Meng H, et al. Biochem Biophys Res Commun, 2021 Apr 30. PMID 33725575
    4. Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Carlson P, et al. Toxicol Sci, 2013 Jul. PMID 23570992
    5. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Mesquita SR, et al. Environ Pollut, 2015 Nov. PMID 26298234

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase B
    Names
    zte141
    NP_001103491.2
    NP_001315354.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110021.2 → NP_001103491.2  carboxypeptidase B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in its 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL935306
      UniProtKB/TrEMBL
      A0A8M1NG52

    2. NM_001328425.1 → NP_001315354.1  carboxypeptidase B isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL935306, BC067637, EE688842
      UniProtKB/TrEMBL
      A0A0R4ILM4, A0A8M1P961, F1QJN9, Q6NWD1
      Related
      ENSDARP00000109376.2, ENSDART00000121576.4
      Conserved Domains (2) summary
      cd03871
      Location:112 → 412
      M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
      pfam02244
      Location:27 → 99
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      4755389..4765724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395164.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      198450..208785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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