lman2la lectin, mannose-binding 2-like a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lman2laprovided by ZNC
Official Full Name: lectin, mannose-binding 2-like aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040715-4
See related: AllianceGenome:ZFIN:ZDB-GENE-040715-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lman2l; VIP36-like; zgc:113949
Summary: Acts upstream of or within mechanosensory lateral line system development. Predicted to be located in membrane. Is expressed in neuromast and neuromast support cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (72377823..72383840)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (71593317..71599334)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

Z9022 (e-PCR)
- UniSTS:11808

G46097 (e-PCR)
- UniSTS:106899

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mechanosensory lateral line system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lectin, mannose-binding 2-like a

Names: vesicular integral-membrane protein VIP36-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205725.2 → NP_991288.2 lectin, mannose-binding 2-like a precursor

See identical proteins and their annotated locations for NP_991288.2

Status: PROVISIONAL

Source sequence(s)

BC097031

UniProtKB/TrEMBL

Q4QRF6

Conserved Domains (1) summary

cl14058
Location:27 → 283

lectin_L-type; legume lectins