gpx4b glutathione peroxidase 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gpx4bprovided by ZNC
Official Full Name: glutathione peroxidase 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030410-3
See related: Ensembl:ENSDARG00000076836 AllianceGenome:ZFIN:ZDB-GENE-030410-3
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb692; PHGPxb; zgc:110018
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development. This isozyme is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A paralog of this gene is present on chromosome 22. Each paralog has a distinct pattern of expression during embryonic development. [provided by RefSeq, Aug 2017]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (56642138..56655769, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (56518293..56531924, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

maternal loss of zebrafish gpx4b promotes embryonic dorsal organizer formation.
Title: Glutathione peroxidase 4 inhibits Wnt/β-catenin signaling and regulates dorsal organizer formation in zebrafish embryos.
We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene expression in the periderm covering the yolk cell only.
Title: Spatial and temporal expression of zebrafish glutathione peroxidase 4 a and b genes during early embryo development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipid hydroperoxide glutathione peroxidase GPX4

NP_001025241.2

EC 1.11.1.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030070.2 → NP_001025241.2 phospholipid hydroperoxide glutathione peroxidase GPX4

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant, and a selenoprotein-encoding transcript.

Source sequence(s)

BC095133, EH448029, EH477511

UniProtKB/TrEMBL

A0A8M1N743

Related

ENSDARP00000154635.1, ENSDART00000191786.1

Conserved Domains (2) summary

cd00340
Location:34 → 187

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

pfam00578
Location:37 → 173

AhpC-TSA; AhpC/TSA family

RNA

NR_144467.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

EB863645, EH448029, EH477511

Related

ENSDART00000113589.4