sec61a1a SEC61 translocon subunit alpha 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sec61a1aprovided by ZNC
Official Full Name: SEC61 translocon subunit alpha 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020418-2
See related: Ensembl:ENSDARG00000021669 AllianceGenome:ZFIN:ZDB-GENE-020418-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sec61a; fb62c11; sec61a1; sec61al1; chunp6898; wu:fb62c11
Summary: Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in pronephric nephron development. Acts upstream of or within habenula development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Is expressed in several structures, including axis; digestive system; hatching gland; midbrain hindbrain boundary; and polster. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (40065210..40071908, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (40067674..40074361, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A screen for mutations that affect habenular laterality led to the identification of the sec61a-like 1(sec61al1) gene.
Title: Subnuclear development of the zebrafish habenular nuclei requires ER translocon function.

Submit: New GeneRIF Correction

General gene information

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Markers

fb62c11 (e-PCR)
- UniSTS:187314

fi14c09.x1 (e-PCR)
- UniSTS:196844

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables signal sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cotranslational protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within habenula development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pronephric nephron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein transport protein Sec61 subunit alpha-like 1

Names: SEC61 translocon alpha 1 subunit; SEC61 translocon subunit alpha 1; SEC61, alpha subunit; Sec61 alpha 1 subunit; Sec61 alpha like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153659.2 → NP_705945.2 protein transport protein Sec61 subunit alpha-like 1

Status: VALIDATED

Source sequence(s)

CU467879

UniProtKB/Swiss-Prot

Q7ZU31, Q7ZUL2, Q90YL4, Q90ZM2

Related

ENSDARP00000033318.6, ENSDART00000034730.8