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    cdk1 cyclin dependent kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 80973, updated on 17-Dec-2024

    Summary

    Official Symbol
    cdk1provided by ZNC
    Official Full Name
    cyclin dependent kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010320-1
    See related
    Ensembl:ENSDARG00000087554 AllianceGenome:ZFIN:ZDB-GENE-010320-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cdc2; zgc:92032; wu:fc30e01
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within neural retina development and regulation of mitotic cell cycle, embryonic. Predicted to be active in nucleus. Is expressed in ciliary marginal zone and eye. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See cdk1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (20923691..20929461)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (20903855..20909625)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 6a Neighboring gene ankyrin 3a Neighboring gene transmembrane protein 26a Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein-like a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC92032

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 1
    Names
    cell division cycle 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212564.2NP_997729.1  cyclin-dependent kinase 1

      See identical proteins and their annotated locations for NP_997729.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079527
      UniProtKB/TrEMBL
      Q6AXI2, Q7T3L7
      Related
      ENSDARP00000109027.1, ENSDART00000122407.3
      Conserved Domains (2) summary
      PLN00009
      Location:1290
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07861
      Location:3287
      STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      20923691..20929461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394983.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      257450..263220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)