ndrg4 NDRG family member 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndrg4provided by ZNC
Official Full Name: NDRG family member 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-060512-226
See related: Ensembl:ENSDARG00000103937 AllianceGenome:ZFIN:ZDB-GENE-060512-226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136766; si:ch211-194m7.2
Summary: Acts upstream of or within cardiac muscle cell proliferation; clustering of voltage-gated sodium channels; and heart looping. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including basal plate midbrain region; cardiovascular system; gut; nervous system; and spinal cord neural tube. Orthologous to human NDRG4 (NDRG family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (13332280..13390072, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (13235775..13293715, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular analysis of ndrg4 mutants shows that expression of snap25 and nsf are sharply decreased, revealing a role of ndrg4 in controlling vesicle exocytosis. This uncovers a previously unknown function of ndrg4 in regulating vesicle docking and nodes of Ranvier organization, at least through its ability to finely tune the expression of the t-SNARE/NSF machinery.
Title: Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish.
Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish.
Title: Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish.

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General gene information

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Markers

fi26d08.x1 (e-PCR)
- UniSTS:197129

G39628 (e-PCR)
- UniSTS:850

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within clustering of voltage-gated sodium channels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein NDRG4

Names: N-myc downstream regulated gene 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045173.2 → NP_001038638.1 protein NDRG4

Status: VALIDATED

Source sequence(s)

AL772241, BC116615, DQ649010

UniProtKB/TrEMBL

A0A0R4ICQ1, A0A8M1NA46, Q1JPS5

Related

ENSDARP00000130451.1, ENSDART00000163735.2

Conserved Domains (2) summary

COG0596
Location:62 → 285

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:8 → 290

Ndr; Ndr family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

13332280..13390072 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163082.5 → XP_005163139.1 protein NDRG4 isoform X8

See identical proteins and their annotated locations for XP_005163139.1

UniProtKB/TrEMBL

A0A8M2BA48, A6XCT1, Q1JPS5

Related

ENSDARP00000141868.1, ENSDART00000169119.2

Conserved Domains (2) summary

COG0596
Location:62 → 285

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:8 → 290

Ndr; Ndr family
XM_068217414.1 → XP_068073515.1 protein NDRG4 isoform X2

UniProtKB/TrEMBL

A0A8M2BA65
XM_005163081.5 → XP_005163138.1 protein NDRG4 isoform X7

UniProtKB/TrEMBL

A0A8M9P6H2, Q1JPS5

Conserved Domains (1) summary

pfam03096
Location:40 → 322

Ndr; Ndr family
XM_005163079.5 → XP_005163136.1 protein NDRG4 isoform X5

See identical proteins and their annotated locations for XP_005163136.1

UniProtKB/TrEMBL

A0A8M2BA65, A0A8M2BA87

Conserved Domains (2) summary

COG0596
Location:139 → 362

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:85 → 367

Ndr; Ndr family
XM_005163080.5 → XP_005163137.1 protein NDRG4 isoform X6

UniProtKB/TrEMBL

A0A8M2BA26, A0A8M2BA65

Conserved Domains (2) summary

COG0596
Location:123 → 346

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:69 → 351

Ndr; Ndr family
XM_005163077.5 → XP_005163134.1 protein NDRG4 isoform X3

UniProtKB/TrEMBL

A0A8M2BA44, A0A8M2BA65

Conserved Domains (2) summary

COG0596
Location:168 → 391

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:114 → 396

Ndr; Ndr family
XM_021470527.2 → XP_021326202.1 protein NDRG4 isoform X7

UniProtKB/TrEMBL

A0A8M9P6H2, Q1JPS5

Conserved Domains (1) summary

pfam03096
Location:40 → 322

Ndr; Ndr family
XM_009297861.4 → XP_009296136.1 protein NDRG4 isoform X5

See identical proteins and their annotated locations for XP_009296136.1

UniProtKB/TrEMBL

A0A8M2BA65, A0A8M2BA87

Conserved Domains (2) summary

COG0596
Location:139 → 362

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:85 → 367

Ndr; Ndr family
XM_068217415.1 → XP_068073516.1 protein NDRG4 isoform X4

UniProtKB/TrEMBL

A0A8M2BA65
XM_068217413.1 → XP_068073514.1 protein NDRG4 isoform X1

UniProtKB/TrEMBL

A0A8M2BA65