uros uroporphyrinogen III synthase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: urosprovided by ZNC
Official Full Name: uroporphyrinogen III synthaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040323-2
See related: Ensembl:ENSDARG00000027491 AllianceGenome:ZFIN:ZDB-GENE-040323-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fd13d11; zgc:110240
Summary: Predicted to enable uroporphyrinogen-III synthase activity. Predicted to be involved in uroporphyrinogen III biosynthetic process. Predicted to act upstream of or within tetrapyrrole biosynthetic process. Predicted to be active in cytosol. Is expressed in hematopoietic system; mesoderm; and notochord. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (48674381..48682752)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (48750746..48759117, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables uroporphyrinogen-III synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables uroporphyrinogen-III synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tetrapyrrole biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in uroporphyrinogen III biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within uroporphyrinogen III biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uroporphyrinogen-III synthase

NP_997993.2

EC 4.2.1.75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212828.2 → NP_997993.2 uroporphyrinogen-III synthase

See identical proteins and their annotated locations for NP_997993.2

Status: PROVISIONAL

Source sequence(s)

BC092818

UniProtKB/TrEMBL

Q568K6

Related

ENSDARP00000096080.3, ENSDART00000105309.5

Conserved Domains (1) summary

cd06578
Location:3 → 255

HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...