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    asap2b ArfGAP with SH3 domain, ankyrin repeat and PH domain 2b [ Danio rerio (zebrafish) ]

    Gene ID: 560581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asap2bprovided by ZNC
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5060
    See related
    Ensembl:ENSDARG00000019564 AllianceGenome:ZFIN:ZDB-GENE-030131-5060
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe36f09; wu:fe36f09; zgc:158353; si:dkey-81b15.3
    Summary
    Predicted to enable GTPase activator activity. Predicted to act upstream of or within positive regulation of GTPase activity. Predicted to be located in cytoplasm. Orthologous to human ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See asap2b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (29634654..29675233)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (29731738..29772575)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 17b Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene uncharacterized LOC137488660 Neighboring gene E2F transcription factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158353

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b
    Names
    ddef2
    ddef2b
    development and differentiation enhancing factor family

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044933.2 → NP_001038398.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b

      See identical proteins and their annotated locations for NP_001038398.2

      Status: PROVISIONAL

      Source sequence(s)
      BC129209
      UniProtKB/TrEMBL
      A0A8M2B7N2, A1L1T9
      Related
      ENSDARP00000092330.3, ENSDART00000101556.4
      Conserved Domains (8) summary
      cd11966
      Location:966 → 1021
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:575 → 672
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:297 → 403
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:306 → 393
      PH; PH domain
      pfam01412
      Location:421 → 537
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:606 → 660
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:584 → 617
      ANK; ANK repeat [structural motif]
      cl12013
      Location:34 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      29634654..29675233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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