tagln2 transgelin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tagln2provided by ZNC
Official Full Name: transgelin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-020802-2
See related: Ensembl:ENSDARG00000033466 AllianceGenome:ZFIN:ZDB-GENE-020802-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb223; tagln3; fa92e03; fb11g09; fi27b02; sm22[a]; wu:fa92e03; wu:fb11g09; wu:fi27b02
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within actin cytoskeleton organization; cell morphogenesis; and endothelial cell migration. Located in actin cytoskeleton. Is expressed in several structures, including EVL; anterior axial hypoblast; cardiovascular system; gut; and periderm. Orthologous to human TAGLN2 (transgelin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (37087623..37095457)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (36487470..36495304)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics.
Title: The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics.
cloning and expression; expression in embryonic development observed in vascular, gut, swim bladder, branchial arches, and fin epidermis
Title: Molecular cloning and expression of a smooth muscle-specific gene SM22alpha in zebrafish.

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General gene information

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Markers

fi27b02.x1 (e-PCR)
- UniSTS:197144

fb11b08.x1 (e-PCR)
- UniSTS:190023

AI384951 (e-PCR)
- UniSTS:206706

fa92e03.x1 (e-PCR)
- UniSTS:189659

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transgelin-2

Names: transgelin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201576.1 → NP_963870.1 transgelin-2

See identical proteins and their annotated locations for NP_963870.1

Status: PROVISIONAL

Source sequence(s)

AY398421

UniProtKB/TrEMBL

Q6TGT5

Related

ENSDARP00000049899.5, ENSDART00000049900.7

Conserved Domains (3) summary

COG5199
Location:14 → 187

SCP1; Calponin [Cytoskeleton]

pfam00307
Location:25 → 131

CH; Calponin homology (CH) domain

pfam00402
Location:173 → 196

Calponin; Calponin family repeat