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    letm1 leucine zipper-EF-hand containing transmembrane protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 570745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    letm1provided by ZNC
    Official Full Name
    leucine zipper-EF-hand containing transmembrane protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-154
    See related
    Ensembl:ENSDARG00000056978 AllianceGenome:ZFIN:ZDB-GENE-050522-154
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    KHE; fc31h08; fc58h01; wu:fc31h08; wu:fc58h01; zgc:109969
    Summary
    Predicted to enable calcium:proton antiporter activity. Predicted to be involved in several processes, including calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and protein complex oligomerization. Predicted to act upstream of or within calcium ion transport and potassium ion transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See letm1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (13033838..13100624)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (12901362..12970404)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438971 Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene fibroblast growth factor receptor 3 Neighboring gene uncharacterized LOC108191973

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling. Sun X, et al. Theranostics, 2020. PMID 32641982, Free PMC Article
    2. The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish. Dao P, et al. Life Sci Alliance, 2022 Sep. PMID 35697381, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish.
      Title: The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109969, MGC191626

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium export from the mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inner mitochondrial membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein hexamerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial proton/calcium exchanger protein
    Names
    LETM1 and EF-hand domain-containing protein 1, mitochondrial
    electroneutral mitochondrial K(+)/H(+)exchanger
    let-m1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045208.1 → NP_001038673.1  mitochondrial proton/calcium exchanger protein

      See identical proteins and their annotated locations for NP_001038673.1

      Status: PROVISIONAL

      Source sequence(s)
      BX119973
      UniProtKB/Swiss-Prot
      B8JIA3, Q1LY46
      Related
      ENSDARP00000074011.5, ENSDART00000079558.7
      Conserved Domains (3) summary
      pfam07766
      Location:162 → 417
      LETM1; LETM1-like protein
      cl01888
      Location:579 → 639
      DUF883; Bacterial protein of unknown function (DUF883)
      cl23750
      Location:473 → 604
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      13033838..13100624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212916.1 → XP_068069017.1  mitochondrial proton/calcium exchanger protein isoform X4

      UniProtKB/Swiss-Prot
      B8JIA3, Q1LY46
      Related
      ENSDARP00000131431.1, ENSDART00000159441.3

    2. XM_009307182.3 → XP_009305457.1  mitochondrial proton/calcium exchanger protein isoform X5

      UniProtKB/Swiss-Prot
      B8JIA3, Q1LY46
      UniProtKB/TrEMBL
      A0A8M3AYW7
      Conserved Domains (2) summary
      pfam07766
      Location:162 → 417
      LETM1; LETM1-like protein
      cl01888
      Location:590 → 650
      DUF883; Bacterial protein of unknown function (DUF883)

    3. XM_009307180.3 → XP_009305455.1  mitochondrial proton/calcium exchanger protein isoform X1

      UniProtKB/Swiss-Prot
      B8JIA3, Q1LY46
      UniProtKB/TrEMBL
      A0A8M3AYY0
      Conserved Domains (2) summary
      pfam07766
      Location:162 → 417
      LETM1; LETM1-like protein
      cl01888
      Location:590 → 650
      DUF883; Bacterial protein of unknown function (DUF883)

    4. XM_009307181.3 → XP_009305456.1  mitochondrial proton/calcium exchanger protein isoform X2

      UniProtKB/Swiss-Prot
      B8JIA3, Q1LY46
      UniProtKB/TrEMBL
      A0A8M3BEI6
      Conserved Domains (2) summary
      pfam07766
      Location:162 → 417
      LETM1; LETM1-like protein
      cl01888
      Location:590 → 650
      DUF883; Bacterial protein of unknown function (DUF883)

    5. XM_005156569.4 → XP_005156626.1  mitochondrial proton/calcium exchanger protein isoform X3

      UniProtKB/Swiss-Prot
      B8JIA3, Q1LY46
      UniProtKB/TrEMBL
      A0A8M2B3G3
      Conserved Domains (3) summary
      pfam07766
      Location:162 → 417
      LETM1; LETM1-like protein
      cl01888
      Location:579 → 639
      DUF883; Bacterial protein of unknown function (DUF883)
      cl23750
      Location:473 → 604
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395307.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      88398..148507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LY46.2 GenPept UniProtKB/Swiss-Prot:Q1LY46

    Gene LinkOut

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