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    rap1ab RAP1A, member of RAS oncogene family b [ Danio rerio (zebrafish) ]

    Gene ID: 406714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rap1abprovided by ZNC
    Official Full Name
    RAP1A, member of RAS oncogene family bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2738
    See related
    Ensembl:ENSDARG00000087346 AllianceGenome:ZFIN:ZDB-GENE-040426-2738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56630
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within convergent extension involved in gastrulation and embryonic cranial skeleton morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rap1ab in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (15833565..15875054, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (15698642..15740419, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 11 Neighboring gene uncharacterized LOC137490700 Neighboring gene uncharacterized LOC137496681 Neighboring gene pantothenate kinase 4 (inactive) Neighboring gene dorsal inhibitory axon guidance protein a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Small molecule inhibition of RAS/MAPK signaling ameliorates developmental pathologies of Kabuki Syndrome. Tsai IC, et al. Sci Rep, 2018 Jul 17. PMID 30018450, Free PMC Article
    2. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. Bögershausen N, et al. J Clin Invest, 2015 Sep. PMID 26280580, Free PMC Article
    3. Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Rho SS, et al. Dev Cell, 2019 Jun 3. PMID 31006651
    4. Dual role of Jam3b in early hematopoietic and vascular development. Kobayashi I, et al. Development, 2020 Jan 8. PMID 31852685
    5. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rap protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within convergent extension involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein rap1ab
    Names
    ras-related protein Rap-1b-like
    NP_001230108.1
    NP_998570.2
    XP_021335265.1
    XP_068080240.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243179.1 → NP_001230108.1  ras-related protein rap1ab

      See identical proteins and their annotated locations for NP_001230108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH543099, FP003590
      UniProtKB/TrEMBL
      A0A8M1PJC7, E7FBI4
      Related
      ENSDARP00000130669.1, ENSDART00000165836.3
      Conserved Domains (1) summary
      cd04175
      Location:3 → 167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    2. NM_213405.2 → NP_998570.2  ras-related protein rap1ab

      See identical proteins and their annotated locations for NP_998570.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      FP003590
      UniProtKB/TrEMBL
      A0A8M1PJC7, E7FBI4
      Related
      ENSDARP00000110237.1, ENSDART00000129526.3
      Conserved Domains (1) summary
      cd04175
      Location:3 → 167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      15833565..15875054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479590.2 → XP_021335265.1  ras-related protein rap1ab isoform X1

      UniProtKB/TrEMBL
      A0A8M1PJC7, E7FBI4
      Conserved Domains (1) summary
      cd04175
      Location:3 → 167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    2. XM_068224139.1 → XP_068080240.1  ras-related protein rap1ab isoform X1

      UniProtKB/TrEMBL
      A0A8M1PJC7, E7FBI4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394809.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      6282..47771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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