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    tjp3 tight junction protein 3 [ Danio rerio (zebrafish) ]

    Gene ID: 373089, updated on 9-Dec-2024

    Summary

    Official Symbol
    tjp3provided by ZNC
    Official Full Name
    tight junction protein 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030828-10
    See related
    Ensembl:ENSDARG00000002909 AllianceGenome:ZFIN:ZDB-GENE-030828-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zo-3; cb766; wu:fj93c08
    Summary
    Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within multicellular organismal-level water homeostasis. Located in bicellular tight junction. Is expressed in several structures, including digestive system; integument; mesoderm; pleuroperitoneal region; and sensory system. Orthologous to human TJP3 (tight junction protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See tjp3 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (17657601..17688868, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (17632519..17663890, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 45b Neighboring gene RNA polymerase II, I and III subunit E, b Neighboring gene strawberry notch homolog 2b Neighboring gene transmembrane 6 superfamily member 2b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of endothelial intestinal barrier IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within multicellular organismal-level homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal-level water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood-brain barrier permeability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tight junction protein ZO-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328340.1NP_001315269.1  tight junction protein ZO-3

      Status: VALIDATED

      Source sequence(s)
      CU695074, CU856138
      UniProtKB/TrEMBL
      A0A8M2BHQ8, F1R3X0
      Related
      ENSDARP00000025259.10, ENSDART00000012336.10
      Conserved Domains (6) summary
      COG0265
      Location:652704
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:1095
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:632700
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam05750
      Location:444565
      Rubella_Capsid; Rubella capsid protein
      cl17036
      Location:725789
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8311005
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      17657601..17688868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170442.5XP_005170499.1  tight junction protein ZO-3 isoform X1

      See identical proteins and their annotated locations for XP_005170499.1

      UniProtKB/TrEMBL
      A0A8M2BHQ8, F1R3X0
      Conserved Domains (6) summary
      COG0265
      Location:652704
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:1095
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:632700
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam05750
      Location:444565
      Rubella_Capsid; Rubella capsid protein
      cl17036
      Location:725789
      SH3; Src Homology 3 domain superfamily
      cl17190
      Location:8311005
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201494.1: Suppressed sequence

      Description
      NM_201494.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.