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    cdc7 cell division cycle 7 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 492768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdc7provided by ZNC
    Official Full Name
    cell division cycle 7 homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-113
    See related
    Ensembl:ENSDARG00000023584 AllianceGenome:ZFIN:ZDB-GENE-041114-113
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7138214; zgc:101602
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in double-strand break repair via break-induced replication and signal transduction. Predicted to act upstream of or within cell division and protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in head and post-vent region. Orthologous to human CDC7 (cell division cycle 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdc7 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (10863938..10877754, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (11080352..11094171, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 2 Neighboring gene glomulin, FKBP associated protein a Neighboring gene transcription elongation factor A (SII) N-terminal and central domain containing 2 Neighboring gene CUB domain containing protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression. Jung IH, et al. Neoplasia, 2019 Oct. PMID 31450023, Free PMC Article
    2. The splicing factor DHX38 enables retinal development through safeguarding genome integrity. Sun K, et al. iScience, 2023 Nov 17. PMID 37867960, Free PMC Article
    3. Distinct requirements for Wntless in habenular development. Kuan YS, et al. Dev Biol, 2015 Oct 15. PMID 26116173, Free PMC Article
    4. Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Li J, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33476374, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle 7-related protein kinase
    NP_001007410.1
    XP_005171217.1
    XP_005171218.1
    XP_005171219.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007409.1 → NP_001007410.1  cell division cycle 7-related protein kinase

      See identical proteins and their annotated locations for NP_001007410.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085380
      UniProtKB/TrEMBL
      Q5U3V5
      Related
      ENSDARP00000091380.3, ENSDART00000100607.6
      Conserved Domains (2) summary
      smart00220
      Location:46 → 332
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14019
      Location:45 → 341
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      10863938..10877754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171162.5 → XP_005171219.1  cell division cycle 7-related protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8M2BID8, B0UYH9
      Related
      ENSDARP00000118103.1, ENSDART00000138718.3
      Conserved Domains (2) summary
      smart00220
      Location:46 → 364
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14019
      Location:45 → 373
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

    2. XM_005171161.5 → XP_005171218.1  cell division cycle 7-related protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8M2BIV6
      Conserved Domains (3) summary
      smart00220
      Location:46 → 390
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14019
      Location:45 → 399
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:300 → 481
      PKc_like; Protein Kinases, catalytic domain

    3. XM_005171160.5 → XP_005171217.1  cell division cycle 7-related protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIF5, B0UYI0
      Related
      ENSDARP00000032739.5, ENSDART00000034246.6
      Conserved Domains (2) summary
      cd14019
      Location:45 → 431
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:332 → 513
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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