cfl1l cofilin 1 (non-muscle), like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cfl1lprovided by ZNC
Official Full Name: cofilin 1 (non-muscle), likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2770
See related: Ensembl:ENSDARG00000012972 AllianceGenome:ZFIN:ZDB-GENE-040426-2770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb86; cfl1; sb:cb86; zgc:56501; wu:fb18a04; wu:fk77b03
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament fragmentation and actin filament severing. Predicted to act upstream of or within actin filament depolymerization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in EVL; epidermis; periderm; pharyngeal arch 3-7 skeleton; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (33606701..33609433)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (33497156..33499888)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish
Title: Loss of cofilin 1 disturbs actin dynamics, adhesion between enveloping and deep cell layers and cell movements during gastrulation in zebrafish.
Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability
Title: Cofilin-1 inactivation leads to proteinuria--studies in zebrafish, mice and humans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb18a04.x1 (e-PCR)
- UniSTS:190221

fb18a04.x1 (e-PCR)
- UniSTS:190222

fl16b01.x1 (e-PCR)
- UniSTS:202010

fk77b03.x1 (e-PCR)
- UniSTS:201523

AI397450 (e-PCR)
- UniSTS:206650

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament depolymerization	IEA Inferred from Electronic Annotation more info
involved_in actin filament fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: non-muscle cofilin 1-like

Names: non-muscle cofilin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.