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    actl6a actin-like 6A [ Danio rerio (zebrafish) ]

    Gene ID: 192313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    actl6aprovided by ZNC
    Official Full Name
    actin-like 6Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-36
    See related
    Ensembl:ENSDARG00000070828 AllianceGenome:ZFIN:ZDB-GENE-020419-36
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    baf53a; fb52e06; fl26e12; chunp6900; wu:fb52e06; wu:fl26e12
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in chromatin remodeling; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be part of NuA4 histone acetyltransferase complex and SWI/SNF complex. Is expressed in ventricular zone. Orthologous to human ACTL6A (actin like 6A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See actl6a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (29386774..29395705)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (29396168..29405144)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene si:ch211-201h21.5 Neighboring gene transmembrane protein 131 Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene NADH:ubiquinone oxidoreductase subunit B5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. psoriasis regulates epidermal development in zebrafish. Webb AE, et al. Dev Dyn, 2008 Apr. PMID 18351656
    2. Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. Aanes H, et al. BMC Genomics, 2013 May 15. PMID 23676078, Free PMC Article
    3. Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS. Taylor R, et al. Nat Commun, 2022 Nov 22. PMID 36414621, Free PMC Article
    4. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. Staahl BT, et al. J Neurosci, 2013 Jun 19. PMID 23785148, Free PMC Article
    5. Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Lee HJ, et al. Genome Biol, 2020 Feb 27. PMID 32106888, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    actin-like protein 6A
    Names
    BRG1/brm-associated factor 53A
    etID38198.6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173240.1 → NP_775347.1  actin-like protein 6A

      See identical proteins and their annotated locations for NP_775347.1

      Status: PROVISIONAL

      Source sequence(s)
      AY099520
      UniProtKB/TrEMBL
      Q8JGS6
      Related
      ENSDARP00000095078.3, ENSDART00000104303.5
      Conserved Domains (2) summary
      pfam00022
      Location:11 → 429
      Actin; Actin
      cl17037
      Location:10 → 428
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      29386774..29395705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165917.5 → XP_005165974.1  actin-like protein 6A isoform X1

      UniProtKB/TrEMBL
      A0A8M2BD91
      Conserved Domains (2) summary
      pfam00022
      Location:11 → 455
      Actin; Actin
      cl17037
      Location:10 → 454
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394647.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      106894..115777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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