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    qsox1 quiescin Q6 sulfhydryl oxidase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100004382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qsox1provided by ZNC
    Official Full Name
    quiescin Q6 sulfhydryl oxidase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7019
    See related
    Ensembl:ENSDARG00000039459 AllianceGenome:ZFIN:ZDB-GENE-030131-7019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk65c10; sb:cb840; im:6793551; wu:fc30g09; wu:fk65c10; si:dkey-39n1.2
    Summary
    Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Predicted to be involved in protein folding. Predicted to be located in membrane. Predicted to be active in Golgi membrane and extracellular space. Is expressed in several structures, including diencephalon; liver; pronephric duct; solid lens vesicle; and yolk syncytial layer. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See qsox1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (14503610..14554785, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (14465905..14517080, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA binding domain containing 6 Neighboring gene LIM homeobox 4 Neighboring gene centrosomal protein 350 Neighboring gene uncharacterized LOC137496331

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Niksirat H, et al. J Proteome Res, 2021 Aug 6. PMID 34185526
    2. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sulfhydryl oxidase 1
    NP_001121836.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128364.1 → NP_001121836.1  sulfhydryl oxidase 1

      Status: PROVISIONAL

      Source sequence(s)
      CR381643
      UniProtKB/TrEMBL
      A0A8M1NHY3, B0UXN0
      Related
      ENSDARP00000057644.5, ENSDART00000057645.6
      Conserved Domains (2) summary
      cd02992
      Location:48 → 161
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:417 → 508
      Evr1_Alr; Erv1 / Alr family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      14503610..14554785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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