mxa myxovirus (influenza) resistance A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mxaprovided by ZNC
Official Full Name: myxovirus (influenza) resistance Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030721-5
See related: Ensembl:ENSDARG00000021688 AllianceGenome:ZFIN:ZDB-GENE-030721-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Mx; fj23d12; wu:fj23d12; zgc:136725
Summary: Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within response to arsenic-containing substance; response to bacterium; and response to virus. Predicted to be active in several cellular components, including cytoplasm; microtubule; and nucleus. Is expressed in several structures, including digestive system; gill; heart; immune system; and muscle. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to several human genes including MX2 (MX dynamin like GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (7562323..7570219, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (6878890..6886786, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning and analysis of an Mx gene and its corresponding promoter
Title: Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio.

Submit: New GeneRIF Correction

General gene information

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Markers

fj23d12.y1 (e-PCR)
- UniSTS:198825

AW202878 (e-PCR)
- UniSTS:205565

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon-induced GTP-binding protein MxA

Names: IFN-inducible antiviral protein MxA; interferon-inducible MxA protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182942.4 → NP_891987.2 interferon-induced GTP-binding protein MxA

Status: VALIDATED

Source sequence(s)

CT998565

UniProtKB/Swiss-Prot

Q8JH68

UniProtKB/TrEMBL

A0A8M1PAS6, B8JKI3

Related

ENSDARP00000094364.3, ENSDART00000103588.5

Conserved Domains (3) summary

cd08771
Location:35 → 307

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:228 → 510

Dynamin_M; Dynamin central region

pfam02212
Location:547 → 632

GED; Dynamin GTPase effector domain