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    lmo1 LIM domain only 1 [ Danio rerio (zebrafish) ]

    Gene ID: 280646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lmo1provided by ZNC
    Official Full Name
    LIM domain only 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021115-6
    See related
    Ensembl:ENSDARG00000034504 AllianceGenome:ZFIN:ZDB-GENE-021115-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb524; lmo1b; wu:fb76g02; zgc:109794; etID41074.7
    Summary
    Predicted to enable DNA-binding transcription factor binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior axial hypoblast; brain; neural tube; pancreas primordium; and presumptive diencephalon. Orthologous to human LMO1 (LIM domain only 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lmo1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (28109362..28148312, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (27838169..27877119, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene TUB bipartite transcription factor Neighboring gene RIC3 acetylcholine receptor chaperone a Neighboring gene uncharacterized LOC108190676 Neighboring gene serine/threonine kinase 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state. Weichert-Leahey N, et al. J Clin Invest, 2023 May 15. PMID 37183825, Free PMC Article
    2. Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4. Lane ME, et al. Mech Dev, 2002 Dec. PMID 14516683
    3. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Zhu S, et al. Cancer Cell, 2017 Sep 11. PMID 28867147, Free PMC Article
    4. TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Lobbardi R, et al. Cancer Discov, 2017 Nov. PMID 28974511, Free PMC Article
    5. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Langenau DM, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15827121, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109794

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    rhombotin-1
    Names
    LIM domain only protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328502.1 → NP_001315431.1  rhombotin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI544617, BX072554, CU651636, EH453517
      UniProtKB/TrEMBL
      A0A0R4IIA9, A0A8M1P988
      Related
      ENSDARP00000135314.1, ENSDART00000158921.3
      Conserved Domains (2) summary
      cd09388
      Location:43 → 97
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:107 → 161
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    2. NM_173219.3 → NP_775326.1  rhombotin-1 isoform 1

      See identical proteins and their annotated locations for NP_775326.1

      Status: VALIDATED

      Source sequence(s)
      AI544617, BX072554, CU651636, EH453517
      UniProtKB/Swiss-Prot
      Q8JFQ2
      UniProtKB/TrEMBL
      B2GQX2
      Related
      ENSDARP00000044207.4, ENSDART00000044208.6
      Conserved Domains (2) summary
      cd09388
      Location:23 → 77
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:87 → 141
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      28109362..28148312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477389.2 → XP_021333064.1  rhombotin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q7H5
      Conserved Domains (2) summary
      cd09388
      Location:27 → 81
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:91 → 145
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    2. XM_021477388.2 → XP_021333063.1  rhombotin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q161
      Conserved Domains (2) summary
      cd09388
      Location:47 → 101
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:111 → 165
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JFQ2.1 GenPept UniProtKB/Swiss-Prot:Q8JFQ2

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