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    f13a1a.1 coagulation factor XIII, A1 polypeptide a, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 767742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    f13a1a.1provided by ZNC
    Official Full Name
    coagulation factor XIII, A1 polypeptide a, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-1250
    See related
    Ensembl:ENSDARG00000045453 AllianceGenome:ZFIN:ZDB-GENE-060929-1250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:152982
    Summary
    Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in blood coagulation, fibrin clot formation. Predicted to act upstream of or within peptide cross-linking. Human ortholog(s) of this gene implicated in artery disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Orthologous to human F13A1 (coagulation factor XIII A chain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See f13a1a.1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (2495197..2515620)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (2499153..2519579)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene coagulation factor XIII A chain Neighboring gene lymphocyte antigen 86 Neighboring gene neuritin 1a Neighboring gene phenylalanyl-tRNA synthetase 2, mitochondrial Neighboring gene LYR motif containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptome profiling analysis of sex-based differentially expressed mRNAs and lncRNAs in the brains of mature zebrafish (Danio rerio). Yuan W, et al. BMC Genomics, 2019 Nov 8. PMID 31703616, Free PMC Article
    2. Characterization of the transglutaminase gene family in zebrafish and in vivo analysis of transglutaminase-dependent bone mineralization. Deasey S, et al. Amino Acids, 2012 Feb. PMID 21809079, Free PMC Article
    3. Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain. Kuil LE, et al. Dis Model Mech, 2019 Mar 8. PMID 30765415, Free PMC Article
    4. Metabolic disruption of zebrafish (Danio rerio) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach. Ortiz-Villanueva E, et al. Environ Pollut, 2017 Dec. PMID 28780062
    5. Identification of estrogen target genes during zebrafish embryonic development through transcriptomic analysis. Hao R, et al. PLoS One, 2013. PMID 24223173, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC152982

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation, fibrin clot formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptide cross-linking IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor XIII, A1 polypeptide a, tandem duplicate 1
    Names
    FXIIIa-42
    f13a1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076711.2 → NP_001070179.2  coagulation factor XIII, A1 polypeptide a, tandem duplicate 1

      Status: VALIDATED

      Source sequence(s)
      CR376727, CR392025
      UniProtKB/TrEMBL
      A0A8M3AP15, F1QC84
      Related
      ENSDARP00000120334.1, ENSDART00000146887.2
      Conserved Domains (3) summary
      smart00460
      Location:310 → 401
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:49 → 159
      Transglut_N; Transglutaminase family
      pfam00927
      Location:629 → 726
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      2495197..2515620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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