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    nde1 nudE neurodevelopment protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 566146, updated on 9-Dec-2024

    Summary

    Official Symbol
    nde1provided by ZNC
    Official Full Name
    nudE neurodevelopment protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-61
    See related
    Ensembl:ENSDARG00000103902 AllianceGenome:ZFIN:ZDB-GENE-050913-61
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb82g01; im:7141877; wu:fb82g01; zgc:114109
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within several processes, including regulation of cell projection size; social behavior; and swimming behavior. Predicted to be located in cytoplasm; microtubule; and spindle. Predicted to be part of kinesin complex. Predicted to be active in centrosome and kinetochore. Human ortholog(s) of this gene implicated in lissencephaly 4. Orthologous to human NDE1 (nudE neurodevelopment protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See nde1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36671592..36684388)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36529734..36542530)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene MPV17 mitochondrial membrane protein like Neighboring gene G1 to S phase transition 1, like Neighboring gene myosin, heavy chain 11b, smooth muscle Neighboring gene ATP binding cassette subfamily C member 1 (ABCC1 blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC114109

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of chromosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuroinflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell projection size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within swimming behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nuclear distribution protein nudE homolog 1
    Names
    nudE nuclear distribution gene E homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030203.1NP_001025374.1  nuclear distribution protein nudE homolog 1

      See identical proteins and their annotated locations for NP_001025374.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097169
      UniProtKB/TrEMBL
      Q4V8W6
      Related
      ENSDARP00000133033.1, ENSDART00000159033.2
      Conserved Domains (2) summary
      pfam04880
      Location:135314
      NUDE_C; NUDE protein, C-terminal conserved region
      cl03075
      Location:50128
      GrpE; nucleotide exchange factor GrpE

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      36671592..36684388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)