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    polk polymerase (DNA directed) kappa [ Danio rerio (zebrafish) ]

    Gene ID: 562749, updated on 4-Jan-2025

    Summary

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    Official Symbol
    polkprovided by ZNC
    Official Full Name
    polymerase (DNA directed) kappaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-137
    See related
    Ensembl:ENSDARG00000059963 AllianceGenome:ZFIN:ZDB-GENE-060526-137
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-254o18.3
    Summary
    Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in error-prone translesion synthesis. Predicted to act upstream of or within DNA biosynthetic process and DNA repair. Predicted to be active in nucleus. Orthologous to human POLK (DNA polymerase kappa). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See polk in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (45895418..45914874)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (45295205..45314310)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 4a Neighboring gene interferon gamma receptor 2 Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene POC5 centriolar protein homolog (Chlamydomonas) Neighboring gene uncharacterized LOC137495626

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. Li Y, et al. FEBS Lett, 2023 Jul. PMID 37259581
    2. Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. Shin U, et al. DNA Repair (Amst), 2021 Nov. PMID 34390914
    3. Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. Casey MA, et al. G3 (Bethesda), 2022 Mar 4. PMID 35079792, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase kappa
    XP_068077613.1
    XP_068077614.1
    XP_691219.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      45895418..45914874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_686127.10 → XP_691219.4  DNA polymerase kappa isoform X1

      See identical proteins and their annotated locations for XP_691219.4

      UniProtKB/TrEMBL
      A0A8N7UR17, E7F6Y7
      Related
      ENSDARP00000078372.5, ENSDART00000083937.6
      Conserved Domains (3) summary
      smart00734
      Location:657 → 682
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd03586
      Location:117 → 512
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      PRK02406
      Location:121 → 522
      PRK02406; DNA polymerase IV; Validated

    2. XM_068221513.1 → XP_068077614.1  DNA polymerase kappa isoform X2

      Related
      ENSDARP00000112656.1, ENSDART00000141039.2

    3. XM_068221512.1 → XP_068077613.1  DNA polymerase kappa isoform X1

      UniProtKB/TrEMBL
      A0A8N7UR17, E7F6Y7
    Nucleotide Protein
    Heading Accession and Version

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