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    acap3b ArfGAP with coiled-coil, ankyrin repeat and PH domains 3b [ Danio rerio (zebrafish) ]

    Gene ID: 100009646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acap3bprovided by ZNC
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070209-274
    See related
    Ensembl:ENSDARG00000099240 AllianceGenome:ZFIN:ZDB-GENE-070209-274
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158388
    Summary
    Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be located in endosome membrane. Orthologous to human ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See acap3b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3385104..3494964, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3316940..3475577, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene sulfite oxidase Neighboring gene microspherule protein 1 Neighboring gene pseudouridine synthase like 1 Neighboring gene DEAD-box helicase 19b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083015.1 → NP_001076484.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3b

      See identical proteins and their annotated locations for NP_001076484.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133093
      UniProtKB/TrEMBL
      A0A0R4IBK3, A0A8M9QCW6, A2RUY3
      Related
      ENSDARP00000130278.1, ENSDART00000162369.2
      Conserved Domains (7) summary
      cd07637
      Location:16 → 215
      BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
      cd00204
      Location:668 → 787
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:271 → 367
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:269 → 363
      PH; PH domain
      pfam01412
      Location:403 → 520
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:671 → 759
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:666 → 697
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      3385104..3494964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224075.1 → XP_068080176.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z8L8
    Nucleotide Protein
    Heading Accession and Version

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