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    ank1a ankyrin 1, erythrocytic a [ Danio rerio (zebrafish) ]

    Gene ID: 449796, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ank1aprovided by ZNC
    Official Full Name
    ankyrin 1, erythrocytic aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-44
    See related
    Ensembl:ENSDARG00000059093 Ensembl:ENSDARG00000092143 AllianceGenome:ZFIN:ZDB-GENE-041010-44
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ank1; wu:fa09h06; zgc:101835; si:ch211-173b16.3
    Summary
    Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Human ortholog(s) of this gene implicated in anemia; hereditary spherocytosis; and hereditary spherocytosis type 1. Orthologous to human ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ank1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (68890479..69115686, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (68126794..68270711, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene surfactant protein Bb Neighboring gene southpaw Neighboring gene microRNA mir-2188 Neighboring gene solute carrier family 25 member 45 Neighboring gene glucosidase II alpha subunit a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A genome-wide map of circular RNAs in adult zebrafish. Sharma D, et al. Sci Rep, 2019 Mar 5. PMID 30837568, Free PMC Article
    2. Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation. Xue Y, et al. Dev Biol, 2015 Jul 15. PMID 26015096
    3. Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Moore C, et al. Blood Adv, 2018 Oct 23. PMID 30309860, Free PMC Article
    4. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin-1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005969.2 → NP_001005969.2  ankyrin-1a isoform 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      CT033825
      UniProtKB/TrEMBL
      A0A8M1N290, B8JK16
      Related
      ENSDARP00000104092.2, ENSDART00000109053.3

    2. NM_001327890.1 → NP_001314819.1  ankyrin-1a isoform 1

      Status: PROVISIONAL

      Source sequence(s)
      CABZ01065994, CABZ01065995, CABZ01065996, CT033825
      UniProtKB/TrEMBL
      A0A0R4IN28, A0A8M1P3X4
      Related
      ENSDARP00000135319.2, ENSDART00000161561.2
      Conserved Domains (9) summary
      smart00218
      Location:931 → 1035
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:337 → 365
      ANK; ankyrin repeats
      COG0666
      Location:341 → 551
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:464 → 589
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:1424 → 1507
      Death_ank1; Death domain of Ankyrin-1
      pfam12796
      Location:210 → 301
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:305 → 358
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:621 → 675
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:667 → 698
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      68890479..69115686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221160.1 → XP_068077261.1  ankyrin-1a isoform X8

    2. XM_021476120.2 → XP_021331795.1  ankyrin-1a isoform X7

      UniProtKB/TrEMBL
      A0A8M9QDU7

    3. XM_005165648.5 → XP_005165705.1  ankyrin-1a isoform X5

      UniProtKB/TrEMBL
      A0A8M2BCX4

    4. XM_005165647.5 → XP_005165704.1  ankyrin-1a isoform X4

      UniProtKB/TrEMBL
      A0A8M2BD04, B8JK17
      Related
      ENSDARP00000116313.1, ENSDART00000141917.3

    5. XM_005165649.5 → XP_005165706.1  ankyrin-1a isoform X6

      UniProtKB/TrEMBL
      A0A0R4IFR3, A0A8M2BD56
      Related
      ENSDARP00000134488.2, ENSDART00000171465.2

    6. XM_068221158.1 → XP_068077259.1  ankyrin-1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PK01, A0A8M9Q363

    7. XM_021476116.2 → XP_021331791.1  ankyrin-1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PK01, A0A8M9Q363
      Conserved Domains (5) summary
      smart00218
      Location:995 → 1099
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:528 → 653
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:731 → 762
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:369 → 422
      Ank_4; Ankyrin repeats (many copies)
      cl14633
      Location:1488 → 1556
      DD; Death Domain Superfamily of protein-protein interaction domains

    8. XM_021476115.2 → XP_021331790.1  ankyrin-1a isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q363, A0A8M9QDU2
      Conserved Domains (5) summary
      smart00218
      Location:995 → 1099
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:528 → 653
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:1488 → 1571
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:731 → 762
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:369 → 422
      Ank_4; Ankyrin repeats (many copies)

    9. XM_021476117.2 → XP_021331792.1  ankyrin-1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PK01, A0A8M9Q363
      Conserved Domains (5) summary
      smart00218
      Location:995 → 1099
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:528 → 653
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:731 → 762
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:369 → 422
      Ank_4; Ankyrin repeats (many copies)
      cl14633
      Location:1488 → 1556
      DD; Death Domain Superfamily of protein-protein interaction domains

    10. XM_021476118.2 → XP_021331793.1  ankyrin-1a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PXF9, A0A8M9Q363
      Conserved Domains (4) summary
      smart00218
      Location:995 → 1099
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:528 → 653
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:731 → 762
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:369 → 422
      Ank_4; Ankyrin repeats (many copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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