get1 guided entry of tail-anchored proteins factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: get1provided by ZNC
Official Full Name: guided entry of tail-anchored proteins factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7696
See related: Ensembl:ENSDARG00000074271 AllianceGenome:ZFIN:ZDB-GENE-030131-7696
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pwi; wrb; wu:ft06h05; zgc:101856
Summary: Predicted to enable protein-membrane adaptor activity. Acts upstream of or within several processes, including response to auditory stimulus; startle response; and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum. Is expressed in hair cell; head; retinal cone cell; and trunk. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (5901971..5916820)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (5914120..5928969)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wrb may have tissue-specific functions in the visual system and heart, or can maintain dual functions even in the same tissue. The selectivity of the defects at sensory neuron ribbon synapses suggests unique biosynthetic demands for cells bearing ribbon synapses, but may also point to a novel role for Wrb acting through the GET pathway in synaptic function.
Title: Mutation of wrb, a Component of the Guided Entry of Tail-Anchored Protein Pathway, Disrupts Photoreceptor Synapse Structure and Function.
WRB plays a critical role in synaptic functions in inner-ear hair cells and retinal photoreceptors.
Title: The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auditory stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tail-anchored membrane protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tail-anchored membrane protein insertion into ER membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GET complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guided entry of tail-anchored proteins factor 1

Names: pinball wizard; tail-anchored protein insertion receptor WRB; tryptophan rich basic protein; tryptophan-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.