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    ldlrap1a low density lipoprotein receptor adaptor protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 368278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ldlrap1aprovided by ZNC
    Official Full Name
    low density lipoprotein receptor adaptor protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030328-13
    See related
    Ensembl:ENSDARG00000004311 AllianceGenome:ZFIN:ZDB-GENE-030328-13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ldlrap1; sb:cb50; zgc:56121
    Summary
    Predicted to be active in early endosome. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; axis; cardiovascular system; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in autosomal recessive hypercholesterolemia. Orthologous to human LDLRAP1 (low density lipoprotein receptor adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ldlrap1a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (29337826..29363780)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (29750551..29776557)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene serum response factor binding protein 1 Neighboring gene macoilin 1a Neighboring gene fibronectin type III domain containing 5b Neighboring gene uncharacterized LOC110438130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proprotein convertase subtilisin/kexin type 9 regulates the production of acute-phase reactants from the liver. Jacome Sanz D, et al. Liver Int, 2021 Oct. PMID 34174143
    2. Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain. Wang S, et al. Front Genet, 2017. PMID 29354154, Free PMC Article
    3. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. Ferg M, et al. EMBO J, 2007 Sep 5. PMID 17703193, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    low density lipoprotein receptor adapter protein 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198980.1 → NP_945331.1  low density lipoprotein receptor adapter protein 1a

      See identical proteins and their annotated locations for NP_945331.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045926
      UniProtKB/TrEMBL
      Q7ZVB8
      Related
      ENSDARP00000009785.5, ENSDART00000021396.6
      Conserved Domains (1) summary
      cd13159
      Location:43 → 165
      PTB_LDLRAP-mammal-like; Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) in mammals and similar proteins Phosphotyrosine-binding (PTB) PH-like fold

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      29337826..29363780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159645.4 → XP_005159702.1  low density lipoprotein receptor adapter protein 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6I6
      Conserved Domains (1) summary
      cd13159
      Location:43 → 165
      PTB_LDLRAP-mammal-like; Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) in mammals and similar proteins Phosphotyrosine-binding (PTB) PH-like fold
    Nucleotide Protein
    Heading Accession and Version

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