akap12b A kinase (PRKA) anchor protein 12b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: akap12bprovided by ZNC
Official Full Name: A kinase (PRKA) anchor protein 12bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9753
See related: Ensembl:ENSDARG00000055678 AllianceGenome:ZFIN:ZDB-GENE-030131-9753
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb27; esr1; akap12; fb72g12; sb:cb27; id:ibd1202; wu:fb72g12; wu:fc21c03; si:ch73-192g21.1
Summary: Predicted to enable calmodulin binding activity and protein kinase A binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; bleb assembly; and negative regulation of Rho protein signal transduction. Located in perinuclear region of cytoplasm. Is expressed in several structures, including cardiovascular system; germ ring; mesoderm; nervous system; and tail bud. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (26408837..26467305, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (26509747..26568215, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings provide the first experimental evidence that akap12beta regulates heart laterality via cadherin1.
Title: Akap12beta supports asymmetric heart development via modulating the Kupffer's vesicle formation in zebrafish.
Loss of akap12 function causes severe defects in locomotor activity in zebrafish embryos.
Title: Akap12 is essential for the morphogenesis of muscles involved in zebrafish locomotion.
Zebrafish embryos depleted of akap12 (akap12 morphants) exhibited severe hemorrhages.
Title: AKAP12 regulates vascular integrity in zebrafish.
These results provide an important step forward in understanding the mechanism of Gravin function in cell shape regulation and provide valuable insight into how Gravin acts as a cytoskeletal regulator.
Title: Cell shape regulation by Gravin requires N-terminal membrane effector domains.
Gravin is required for the conversion of mesodermal cells from a highly migratory behavior to the medio-laterally intercalative behavior required for body axis extension.
Title: Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation.

Submit: New GeneRIF Correction

General gene information

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Markers

fb72g12.x1 (e-PCR)
- UniSTS:187422

G39371 (e-PCR)
- UniSTS:33311

AI658298 (e-PCR)
- UniSTS:206074

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bleb assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase A signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of protein kinase C signaling	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within slow muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: A-kinase anchor protein 12b

Names: A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein (gravin) 12b; gravin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098184.2 → NP_001091654.2 A-kinase anchor protein 12b isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' segment, compared to variant 1, that results in a distinct 5' UTR and 5' coding region. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

CU041395, CU179733

UniProtKB/TrEMBL

A0A8M1NDE1, F2Z4T4

Related

ENSDARP00000103304.3, ENSDART00000110883.5

Conserved Domains (1) summary

pfam03832
Location:466 → 493

WSK; WSK motif
NM_001281788.1 → NP_001268717.1 A-kinase anchor protein 12b isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

CU041395, CU179733, EB766946

UniProtKB/TrEMBL

A0A0R4IC31, A0A8M1P4X8

Related

ENSDARP00000131318.1, ENSDART00000158213.2

Conserved Domains (1) summary

pfam03832
Location:529 → 556

WSK; WSK motif