tbpl1 TBP-like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tbpl1provided by ZNC
Official Full Name: TBP-like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040520-2
See related: Ensembl:ENSDARG00000036868 AllianceGenome:ZFIN:ZDB-GENE-040520-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tlf; tlp; trf; trp; trf2; zgc:92340
Summary: Predicted to enable general transcription initiation factor activity. Involved in embryo development and transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (31596529..31605307)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (31669910..31678776)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging.
Title: The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TATA box-binding protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205722.1 → NP_991285.1 TATA box-binding protein-like 1

See identical proteins and their annotated locations for NP_991285.1

Status: PROVISIONAL

Source sequence(s)

AF503448

UniProtKB/Swiss-Prot

Q5U385

Related

ENSDARP00000053533.3, ENSDART00000053534.5

Conserved Domains (2) summary

PLN00062
Location:15 → 184

PLN00062; TATA-box-binding protein; Provisional

cd04517
Location:9 → 180

TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

31596529..31605307

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162305.4 → XP_005162362.1 TATA box-binding protein-like 1 isoform X1

See identical proteins and their annotated locations for XP_005162362.1

UniProtKB/Swiss-Prot

Q5U385, Q71H63

Related

ENSDARP00000134538.1, ENSDART00000160748.2

Conserved Domains (2) summary

PLN00062
Location:15 → 184

PLN00062; TATA-box-binding protein; Provisional

cd04517
Location:9 → 180

TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...