U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ddx19a DEAD-box helicase 19a [ Danio rerio (zebrafish) ]

    Gene ID: 563448, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ddx19aprovided by ZNC
    Official Full Name
    DEAD-box helicase 19aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080721-12
    See related
    Ensembl:ENSDARG00000044325 AllianceGenome:ZFIN:ZDB-GENE-080721-12
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu534; zgc:193690; zgc:193696
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in cytoplasmic stress granule and nucleus. Orthologous to human DDX19A (DEAD-box helicase 19A) and DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ddx19a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (37095432..37113441, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (36992770..37010768, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene UBX domain protein 10 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene von Willebrand factor A domain containing 5B1 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 1b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technology. Chen X, et al. Genome Biol, 2019 Jan 23. PMID 30674345, Free PMC Article
    2. CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos. Huang Y, et al. Genome Biol, 2023 Jan 19. PMID 36658633, Free PMC Article
    3. Evolutionary conservation of maternal RNA localization in fishes and amphibians revealed by TOMO-Seq. Naraine R, et al. Dev Biol, 2022 Sep. PMID 35752299
    4. RNA-sequencing analysis of TCDD-induced responses in zebrafish liver reveals high relatedness to in vivo mammalian models and conserved biological pathways. Li ZH, et al. PLoS One, 2013. PMID 24204792, Free PMC Article
    5. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP-dependent RNA helicase DDX19A
    NP_001122187.1
    XP_068072880.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128715.2 → NP_001122187.1  ATP-dependent RNA helicase DDX19A

      See identical proteins and their annotated locations for NP_001122187.1

      Status: VALIDATED

      Source sequence(s)
      CR846089
      UniProtKB/TrEMBL
      A0A8N7XJD1, B3DFU8, B3DFV2, F6P5R1
      Related
      ENSDARP00000093660.4, ENSDART00000102886.4
      Conserved Domains (3) summary
      PTZ00424
      Location:83 → 461
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:299 → 434
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:86 → 288
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      37095432..37113441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216779.1 → XP_068072880.1  ATP-dependent RNA helicase DDX19A isoform X1

      UniProtKB/TrEMBL
      A0A8N7XJD1, B3DFU8, B3DFV2, F6P5R1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools